CD14 - Recombinant proteins and antibodies

CD14 is the 53-kD glycophosphatidylinositol (GPI)-linked glycoprotein and functions as high affinity endotoxin (LPS) receptor on the surface of monocytes, macrophages and granulocytes as well as brain cells. The CD14-Receptor consists of 326 amino acids. CD14 has opsonin receptor funktion and binds bacterial fatty acids and peptidoglycanes. Together with TLR4 and a lymphocytic antigen (MD2) CD14 is the lipopolysaccharide (LPS)-Receptor and mediates innate immune response to bacterial lipoproteins. In endothelial cells CD14 has regulating function for cell survival. In the presence of LPS CD14-expression can be amplified by TNF-α and IL-1β (in varied tissues differently). Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids which is directly secreted or derived from protease-dependent shedding of the membrane bound molecule. Soluble CD14 (sCD14) competes with membrane bound CD14 (mCD14) for LPS binding and is able to neutralize LPS-induced responses in vitro and in vivo and mediates the LPS-induced activation of non-CD14-expressing endothelial, epithelial and smooth-muscle cells.

   
 

031-1-1.2

Polyclonal antiserum to human CD14

From €100.00 *

031-2-1.2

Polyclonal antiserum to mouse CD14

From €100.00 *